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Spyre Therapeutics, Inc (SYRE)

Red

Health Care · As of 17 July 2026

Price chart — 52 weeks

SYRE · 100.23 (last weekly close) SMA 10w SMA 40w
102030405060708090100AugSepOctNovDec2026FebMarAprMayJunJul10.0MWeek of Jul 21, 2025 · O 16.39 · H 18.31 · L 16.16 · C 17.79 · Vol 2.9MWeek of Jul 28, 2025 · O 17.82 · H 18.00 · L 16.23 · C 16.26 · Vol 3.2MWeek of Aug 4, 2025 · O 16.30 · H 17.01 · L 14.75 · C 15.16 · Vol 2.4MWeek of Aug 11, 2025 · O 15.11 · H 17.42 · L 14.72 · C 16.95 · Vol 1.9MWeek of Aug 18, 2025 · O 16.95 · H 17.80 · L 15.73 · C 17.38 · Vol 3.0MWeek of Aug 25, 2025 · O 17.25 · H 17.46 · L 16.27 · C 16.49 · Vol 1.8MWeek of Sep 1, 2025 · O 16.26 · H 17.58 · L 16.12 · C 17.00 · Vol 1.7MWeek of Sep 8, 2025 · O 16.98 · H 17.13 · L 15.64 · C 15.65 · Vol 2.0MWeek of Sep 15, 2025 · O 15.62 · H 15.84 · L 14.64 · C 14.88 · Vol 4.1MWeek of Sep 22, 2025 · O 14.86 · H 17.12 · L 14.51 · C 16.24 · Vol 4.3MWeek of Sep 29, 2025 · O 16.27 · H 17.19 · L 15.49 · C 15.89 · Vol 2.8MWeek of Oct 6, 2025 · O 16.03 · H 21.51 · L 15.86 · C 19.14 · Vol 6.2MWeek of Oct 13, 2025 · O 19.15 · H 23.49 · L 18.12 · C 22.47 · Vol 12.8MWeek of Oct 20, 2025 · O 22.86 · H 24.03 · L 21.88 · C 23.37 · Vol 4.3MWeek of Oct 27, 2025 · O 24.01 · H 25.06 · L 23.52 · C 24.46 · Vol 4.3MWeek of Nov 3, 2025 · O 23.95 · H 24.45 · L 21.15 · C 22.52 · Vol 3.6MWeek of Nov 10, 2025 · O 22.93 · H 24.50 · L 21.63 · C 23.50 · Vol 2.6MWeek of Nov 17, 2025 · O 23.47 · H 25.42 · L 23.01 · C 24.26 · Vol 2.9MWeek of Nov 24, 2025 · O 24.95 · H 30.21 · L 24.58 · C 30.00 · Vol 2.7MWeek of Dec 1, 2025 · O 30.55 · H 34.54 · L 28.16 · C 33.45 · Vol 4.3MWeek of Dec 8, 2025 · O 33.95 · H 35.31 · L 33.24 · C 33.62 · Vol 4.5MWeek of Dec 15, 2025 · O 33.93 · H 34.96 · L 32.26 · C 33.40 · Vol 6.4MWeek of Dec 22, 2025 · O 32.93 · H 34.52 · L 32.30 · C 32.94 · Vol 2.3MWeek of Dec 29, 2025 · O 32.77 · H 33.31 · L 30.11 · C 30.58 · Vol 2.2MWeek of Jan 5, 2026 · O 30.49 · H 31.69 · L 28.00 · C 30.61 · Vol 3.4MWeek of Jan 12, 2026 · O 30.60 · H 34.21 · L 30.00 · C 33.24 · Vol 3.5MWeek of Jan 19, 2026 · O 32.34 · H 35.07 · L 31.62 · C 32.04 · Vol 2.4MWeek of Jan 26, 2026 · O 31.52 · H 34.03 · L 31.52 · C 31.98 · Vol 2.2MWeek of Feb 2, 2026 · O 31.76 · H 35.21 · L 30.92 · C 35.12 · Vol 3.1MWeek of Feb 9, 2026 · O 35.12 · H 37.98 · L 32.35 · C 36.63 · Vol 3.6MWeek of Feb 16, 2026 · O 36.39 · H 43.56 · L 34.96 · C 43.21 · Vol 4.5MWeek of Feb 23, 2026 · O 43.01 · H 45.76 · L 42.03 · C 43.01 · Vol 3.5MWeek of Mar 2, 2026 · O 41.27 · H 42.93 · L 38.36 · C 40.15 · Vol 3.6MWeek of Mar 9, 2026 · O 39.75 · H 42.93 · L 39.00 · C 39.89 · Vol 3.7MWeek of Mar 16, 2026 · O 40.73 · H 45.39 · L 40.73 · C 41.25 · Vol 4.9MWeek of Mar 23, 2026 · O 42.02 · H 49.31 · L 40.91 · C 47.31 · Vol 4.3MWeek of Mar 30, 2026 · O 47.75 · H 51.06 · L 44.80 · C 47.58 · Vol 3.1MWeek of Apr 6, 2026 · O 47.58 · H 54.39 · L 46.79 · C 51.29 · Vol 3.7MWeek of Apr 13, 2026 · O 67.00 · H 75.00 · L 59.02 · C 73.01 · Vol 15.6MWeek of Apr 20, 2026 · O 72.20 · H 74.84 · L 68.33 · C 69.67 · Vol 4.6MWeek of Apr 27, 2026 · O 69.53 · H 76.00 · L 67.50 · C 69.42 · Vol 6.1MWeek of May 4, 2026 · O 68.26 · H 75.91 · L 67.18 · C 75.05 · Vol 5.5MWeek of May 11, 2026 · O 75.15 · H 78.80 · L 72.54 · C 74.92 · Vol 6.3MWeek of May 18, 2026 · O 75.08 · H 75.65 · L 64.67 · C 74.05 · Vol 4.9MWeek of May 25, 2026 · O 74.87 · H 76.12 · L 71.08 · C 73.50 · Vol 2.6MWeek of Jun 1, 2026 · O 72.39 · H 79.54 · L 68.50 · C 73.65 · Vol 6.0MWeek of Jun 8, 2026 · O 75.53 · H 84.43 · L 70.89 · C 80.79 · Vol 5.8MWeek of Jun 15, 2026 · O 81.57 · H 90.99 · L 80.79 · C 88.34 · Vol 6.5MWeek of Jun 22, 2026 · O 95.00 · H 102.06 · L 81.65 · C 87.89 · Vol 16.0MWeek of Jun 29, 2026 · O 86.56 · H 91.96 · L 84.81 · C 86.63 · Vol 6.1MWeek of Jul 6, 2026 · O 87.27 · H 99.34 · L 86.60 · C 97.74 · Vol 6.0MWeek of Jul 13, 2026 · O 95.72 · H 105.09 · L 92.37 · C 100.23 · Vol 7.8M100
Weekly candles over the last 52 weeks, split-adjusted, with 10- and 40-week moving averages; trading volume along the bottom. As of Jul 13, 2026.

OakBag could not build a reliable fair-value estimate for Spyre Therapeutics, Inc (SYRE) — none of its valuation methods cleared the model's safety checks (typically a company running an operating loss, where a discount can't be trusted). At a recent price of $100.23 the traffic light is set so it looks expensive or risky, benchmarked against other Health Care names. This is a model output for research, not a price target or a recommendation.

Fair value vs. price

Current price
$100.23
Estimated fair value
Margin of safety

How the fair value is built

How is this computed?

Why not green?

  • The company is running an operating loss, so the screen will not flag a money-losing business as a buy.
  • Only one valuation method applies to this business — too thin to flag as a buy on its own.

Knock-out safety checks passed

  • Bankruptcy risk (Altman Z″)
  • Negative equity
  • Excessive leverage
  • Illiquid
  • Penny / micro-cap
  • Stale fundamentals
Piotroski F-score
2 / 9
Altman Z-score
9.69
Beneish M-score
-2.76

Quality & factor profile

Value -0.45
Quality -0.59
Profitability -0.58
Momentum +2.87
Growth -1.53
Low volatility -0.85

See the full analysis

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Frequently asked questions

Is Spyre Therapeutics (SYRE) undervalued?

OakBag could not build a reliable fair-value estimate for Spyre Therapeutics, Inc — none of its valuation methods cleared the model's safety checks, which usually happens for a company running an operating loss. At a recent price of $100.23 the model looks expensive or risky. This is a model output, not investment advice.

What is margin of safety?

Margin of safety is how far below the estimated fair value the price sits: (fair value − price) ÷ fair value. It cannot be shown here because no reliable fair-value estimate could be built for this stock.

Does a green verdict mean I should buy SYRE?

No. OakBag is an educational and research tool, not investment advice. The traffic light is an automated model output based on third-party data that may be delayed or inaccurate. Always do your own research.

Other Health Care stocks

An educational and research tool — not investment advice. OakBag is an educational and research tool, not investment advice. Scores and rankings are automated model outputs based on third-party data and may be inaccurate or delayed. Nothing here is a recommendation to buy or sell any security. Investing involves risk, including possible loss of principal.